| Apoptosis Pathway |
This pathway is responsible for death of cells. Since Alzheimer’s disease is associated with damage of neurons, so Apoptosis has a major role in Alzheimer’s disease38. Genes like MAPT, CASP2 catalyzes Apoptosis. |
| Notch Pathway |
This pathway is responsible for maturation, cell division, and functioning of immune system. Genes like PSEN1, MYC, PSEN2 are associated with Notch pathway. In patients with Alzheimer’s disease, there is mutation in PSEN1 or PSEN2, which leads to deposition of longer form of amyloid beta in AD brains. |
| Wnt Pathway |
Wnt plays an important role in development of neurons in adult brain and this implicate in neurodegenerative disease30. Genes like CSNK1D, DKK1, PIN1, PSEN1, PSEN2 are related to Wnt signaling pathways. |
| p53 signaling pathway |
The p53 tumor suppressor gene is a key gene for apoptosis and activates cell growth. Since death of neuron is associated with Alzheimer’s disease, so p53 signaling pathway is an important regulator of Alzheimer’s disease. Genes like CASP3, CDK5, CREB1 are related to p53 signaling pathway. |
