Figure 2. Pre-treatment with LDActD protects wild type p53 A375 cells but not mutant p53 MDA-MB-231 cells from MLN4924-induced toxicity.

(a) Similar experiment as in Fig. 1 was performed in A375 (wild type p53) and MDA-MB-231 (mutant p53) cells. (b) The average values of 3 independent experiments in (a) are presented as % of cells in G1, S, G2/M. (c) Western blot analysis for the indicated proteins from the experiment performed in (a) (cropped blots). GAPDH was used as loading control.