Table 1.
Inclusion criteria | Exclusion criteria |
---|---|
1. Adult men or women | 1. Participant under prescription for medication for digestive symptoms such as antispasmodic, laxatives and antidiarrhoeic drugs or other digestive auxiliaries |
2. Age 18–60 years | 2. Relevant history, presence of any medical disorder or intake of medication/dietary supplements, potentially interfering with this trial at screening |
3. Healthy volunteers free of chronic diseases with relevant effect on the gastrointestinal system or on visceral motility | 3. Participants with stool frequency of ≤1 stool every 7 days |
4. Without a diagnosis of any digestive disease including functional bowel disorders such as IBS | 4. Participants not willing to avoid prebiotics and probiotics for the duration of the study |
5. Non-diabetic, no gastric bypass surgery | 5. Intake of antibiotics in the past 4 weeks and laxatives in the past 2 weeks |
6. Fasting plasma glucose (finger-stick) <100 mg/dL (<5.5 mmol/L) | 6. Current use of medication for lowering blood cholesterol or glucose |
7. Non-smoker | 7. Change of dietary habits within the 4 weeks prior to screening (for instance, start of a diet high in fibre) |
8. Willing and able to provide written informed consent | 8. Pregnant participant or participant planning to become pregnant during the study; breastfeeding participant |
9. Participants with a history of drug, alcohol or other substance abuse, or other factors limiting their ability to cooperate during the study | |
10. Participants anticipating a change in their lifestyle or physical activity levels since this may also influence the results | |
11. Known food intolerance or allergy | |
12. Participant involved in any clinical or food study within the preceding month |
IBS, irritable bowel syndrome.