Table 4.
Multivariate HRs for OAP treatment discontinuation within 12 months
| HR | 95% CI | p Value | |
|---|---|---|---|
| Other OAP vs clopidogrel | |||
| Prasugrel | 1.40 | 1.25 to 1.58 | <0.001 |
| Ticagrelor | 1.06 | 0.96 to 1.18 | 0.250 |
| Age at index (years) vs ≤65 | |||
| >65 to ≤75 | 1.01 | 0.94 to 1.08 | 0.791 |
| >75 to ≤85 | 1.24 | 1.14 to 1.35 | <0.001 |
| >85 | 1.49 | 1.34 to 1.64 | <0.001 |
| Women vs men | 1.05 | 1.00 to 1.09 | 0.039 |
| Type of index ACS event vs unstable angina pectoris | |||
| STEMI | 0.70 | 0.65 to 0.74 | <0.001 |
| NSTEMI | 0.83 | 0.79 to 0.88 | <0.001 |
| Invasive procedure vs none (during the total index event hospitalisation) | |||
| Coronary angiography only | 1.13 | 1.06 to 1.21 | <0.001 |
| PCI | 0.62 | 0.59 to 0.66 | <0.001 |
| CABG | 0.85 | 0.73 to 0.99 | 0.034 |
| Comorbidity history yes vs no | |||
| Previous OAP use | 0.51 | 0.46 to 0.56 | <0.001 |
| Heart failure | 1.08 | 0.98 to 1.19 | 0.118 |
| Hypertension | 1.16 | 1.10 to 1.24 | <0.001 |
| Hyperlipidaemia | 1.00 | 0.95 to 1.05 | 0.962 |
| Stroke | 1.01 | 0.92 to 1.11 | 0.828 |
| Major bleedings | 1.20 | 1.07 to 1.34 | 0.002 |
| Atrial fibrillation | 1.39 | 1.19 to 1.62 | <0.001 |
| Warfarin use at baseline | 2.21 | 2.01 to 2.44 | <0.001 |
| Diabetes mellitus history | 0.99 | 0.91 to 1.07 | 0.755 |
| Dementia/Alzheimer's disease | 1.47 | 1.24 to 1.75 | <0.001 |
| Charlson Comorbidity Index vs 0 | |||
| 1 | 0.93 | 0.84 to 1.03 | 0.166 |
| 2 | 1.00 | 0.91 to 1.11 | 0.922 |
| 3 to 5 | 1.17 | 1.04 to 1.31 | 0.007 |
| 6 to 9 | 1.32 | 1.14 to 1.52 | <0.001 |
| ≥10 | 1.24 | 0.87 to 1.76 | 0.232 |
| Cohort entry year vs 2009 | |||
| 2010 | 1.05 | 0.99 to 1.12 | 0.105 |
| 2011 | 0.99 | 0.93 to 1.06 | 0.809 |
| 2012 | 1.12 | 1.05 to 1.19 | <0.001 |
| 2013 | 1.05 | 0.97 to 1.13 | 0.212 |
ACS, acute coronary syndrome; CABG, coronary artery bypass grafting; NSTEMI, non-ST elevation myocardial infarction; OAP, oral antiplatelet; PCI, percutaneous coronary intervention; STEMI, ST elevation myocardial infarction.