Table 1. Baseline demographic and clinical characteristics of elderly and younger patients (intent-to-treat population).
| Elderly (≥75 years) | Younger (<75 years) | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Abiraterone-prednisone (n=185) | Prednisone alone (n=165) | P Value | Abiraterone-prednisone (n=361) | Prednisone alone (n=377) | P Value | |
|
| ||||||
| Age, years | 0.4299 | 0.5741 | ||||
| n | 185 | 165 | 361 | 377 | ||
| Median | 79 | 79 | 67 | 66 | ||
| Range | 75–95 | 75–90 | 44–74 | 44–74 | ||
|
| ||||||
| Race, n (%) | ||||||
|
| ||||||
| White | 180 (97.3) | 161 (97.6) | 1.0000 | 340 (94.2) | 349 (92.6) | 0.4653 |
|
| ||||||
| Black | 2 (1.1) | 0 | 13 (3.6) | 13 (3.5) | ||
|
| ||||||
| Asian | 1 (0.5) | 3 (1.8) | 3 (0.8) | 6 (1.6) | ||
|
| ||||||
| Other | 2 (1.1) | 0 | 4 (1.1) | 6 (1.6) | ||
|
| ||||||
| Missing | 0 | 1 (0.6) | 1 (0.3) | 1 (0.3) | ||
|
| ||||||
| Native | 0 | 0 | 0 | 2 (0.5) | ||
|
| ||||||
| Gleason score at initial diagnosis, n (%) | ||||||
|
| ||||||
| n | 158 | 149 | 330 | 359 | ||
|
| ||||||
| ≤7 | 85 (53.8) | 87 (58.4) | 0.4870 | 140 (42.4) | 167 (46.5) | 0.3157 |
|
| ||||||
| ≥8 | 73 (46.2) | 62 (41.6) | 190 (57.6) | 192 (53.5) | ||
|
| ||||||
| PSA at initial diagnosis, ng/ml | 0.2412 | 0.5737 | ||||
|
| ||||||
| n | 152 | 127 | 318 | 327 | ||
|
| ||||||
| Median | 19.1 | 17.4 | 23.8 | 22.3 | ||
|
| ||||||
| Range | 1.4–3273.0 | 0.7–6062.0 | 0.4–5036.0 | 0.3–9726.3 | ||
|
| ||||||
| Extent of disease, n (%) | ||||||
|
| ||||||
| n | 183 | 165 | 361 | 377 | ||
|
| ||||||
| Bone | 153 (83.6) | 129 (78.2) | 299 (82.8) | 303 (80.4) | ||
|
| ||||||
| Soft tissue or node | 85 (46.4) | 79 (47.9) | 182 (50.4) | 192 (50.9) | ||
|
| ||||||
| Bone, soft tissue or node | 183 (100.0) | 165 (100.0) | 361 (100.0) | 377 (100.0) | ||
|
| ||||||
| ECOG PS, n (%) | ||||||
|
| ||||||
| n | 185 | 165 | 361 | 377 | ||
|
| ||||||
| 0 | 115 (62.2) | 107 (64.8) | 0.6820 | 301 (83.4) | 307 (81.4) | 0.5502 |
|
| ||||||
| 1 | 70 (37.8) | 58 (35.2) | 60 (16.6) | 70 (18.6) | ||
|
| ||||||
| Baseline PSA (ng/mL) | 0.0995 | 0.8564 | ||||
|
| ||||||
| n | 185 | 163 | 361 | 376 | ||
|
| ||||||
| Median | 48.4 | 37.8 | 37.6 | 37.5 | ||
|
| ||||||
| Range | 1.8–3927.4 | 0.8–2730.4 | 0.0–1715.7 | 0.7–6606.4 | ||
|
| ||||||
| Baseline hemoglobin, g/dL | 0.3617 | 0.5669 | ||||
|
| ||||||
| n | 184 | 162 | 361 | 376 | ||
|
| ||||||
| Median | 12.7 | 12.9 | 13.3 | 13.2 | ||
|
| ||||||
| Range | 9.3–15.4 | 10.1–15.4 | 7.2–16.6 | 7.0–15.7 | ||
|
| ||||||
| Lactate dehydrogenase (IU/L) | 0.7345 | 0.5810 | ||||
|
| ||||||
| n | 183 | 162 | 360 | 374 | ||
|
| ||||||
| Median | 189.0 | 186.0 | 184.5 | 183.0 | ||
|
| ||||||
| Range | 97–413 | 87–554 | 60–871 | 108–781 | ||