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. Author manuscript; available in PMC: 2017 Feb 19.
Published in final edited form as: ACS Chem Biol. 2015 Dec 14;11(2):435–443. doi: 10.1021/acschembio.5b00639

Figure 2.

Figure 2

In TTP ZF2 is unstructured in the unbound state but folds upon RNA-binding. a) 15N-1H HSQC spectra of RNA free (red)/RNA bound TTP (gray). New cross-peaks, corresponding to residues of the linker and ZF2 of TTP, appear upon addition of RNA. The structural transition occurring upon RNA-binding is depicted on top. The 3D structure of TTP was modeled from that of TIS11d (PDB id: 1RGO)19. b) Far-UV circular dichroism (CD) spectra of TTP (red), TIS11d (blue) and TIS11b (green). The CD spectra of TIS11b and TIS11d are almost entirely overlapped.