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. 2016 Nov 29;17:246. doi: 10.1186/s13059-016-1098-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — OAS-introgressed haplotypes are found at higher frequencies in European populations than expected under neutrality. a Comparison of frequency (y-axis) of NLS in the OAS locus in the CEU, GBR, IBS, and TSI European population samples with respect to neutral expectations (dashed lines) based on coalescent simulations. b Absolute difference between observed and expected allele frequency in the same four present-day European samples (y-axis) based on ancient DNA data. Dashed lines represent the 95th percentile of the expected distribution based on similar deviations calculated on a dataset of approximately 1 million SNPs scattered around the genome and with comparable present-day frequencies to those found for NLS in the OAS region