Table 1.
MiRNAs reported to regulate drug metabolism related genes.
| Function | Gene | Involved miRNA | Identification Methods | References |
|---|---|---|---|---|
| DMEs | CYP1A1 | miR-18b, -20b | Correlation, mRNA expression | [9] |
| miR-892a | Reporter assay, mRNA/protein expression, functional assay | [11] | ||
| CYP2A3 | miR-126* a | mRNA/protein expression | [13] | |
| CYP1B1 | miR-27b | Correlation, Reporter assays, protein expression, functional assay | [14] | |
| CYP2C8 | miR-103, -107 | Reporter assay, mRNA/protein expression, correlation | [17] | |
| CYP2C9 | miR-128-3p | EMSA, reporter assay, mRNA/protein expression, correlation | [18] | |
| CYP2C19 | miR-103, -107 | Protein expression | [17] | |
| miR-29a-3p | EMSA, mRNA/protein expression, correlation | [19] | ||
| CYP2E1 | miR-378 | Reporter assay, mRNA/protein expression, correlation, functional assay | [20] | |
| miR-132, -212 | Reporter assay, mRNA expression | [21] | ||
| CYP2J2 | let-7b | Reporter assay, protein expression, functional assay | [22] | |
| CYP3A4 | miR-27b | Reporter assay, mRNA/protein expression, functional assay | [23] | |
| miR-1, -532-3p, -577, -627 | Reporter assay, protein expression, correlation | [24] | ||
| miR-27a | Reporter assay, mRNA/protein expression, correlation | [26] | ||
| CYP7A1 | miR-122a, -422a a | Reporter assay, mRNA expression | [27] | |
| CYP24A1 | miR-125b | Reporter assay, mRNA/protein expression, functional assay | [29] | |
| Transporters | ABCB1/MDR1 | let-7g | mRNA/protein expression, correlation, functional assay | [33] |
| miR-27a | mRNA/protein expression, functional assay | [34,35] | ||
| miR-451 a | mRNA/protein expression, functional assay | [34,36] | ||
| miR-298 a | Reporter assay, protein expression, functional assay | [37] | ||
| miR-223 | Reporter assay, mRNA/protein expression, functional assay | [38] | ||
| miR-508-5p | Reporter assay, mRNA/protein expression, functional assay | [39] | ||
| miR-145 | Reporter assay, protein expression, functional assay | [40] | ||
| ABCB9 | miR-31 | Reporter assay, mRNA/protein expression, functional assay | [41] | |
| ABCC1/MRP1 | miR-326 | Reporter assay, mRNA/protein expression, functional assays | [43] | |
| miR-134 | mRNA/protein expression | [44] | ||
| miR-122 | mRNA/protein expression, functional assay | [45] | ||
| miR-1291 a | Reporter assay, mRNA/protein expression, and functional assays | [46] | ||
| miR-7 | Reporter assay, mRNA/protein expression, correlation | [47] | ||
| ABCC2/MRP2 | miR-379 | Reporter assay, mRNA/protein expression, functional assays | [48,49] | |
| miR-297 a | Reporter assay, mRNA/protein expression, functional assays | [50] | ||
| let-7c | Reporter assay, mRNA/protein expression, functional assays | [51] | ||
| ABCC4/MRP4 | miR-125a/b | Reporter assay, mRNA expression, correlation | [52] | |
| miR-124a, -506 a | Reporter assay, mRNA/protein expression, correlation, functional assay | [53] | ||
| ABCC5/MRP5 | miR-128 | Reporter assay, protein expression, functional assay | [54] | |
| ABCG2/BCRP | miR-328 | Reporter assay, mRNA/protein expression, functional assays | [57,58,59] | |
| miR-519c | Reporter assay, mRNA/protein expression, functional assays | [60] | ||
| miR-212 | Reporter assay, protein expression | [61] | ||
| miR-520h | Reporter assay, mRNA/protein expression | [62,63] | ||
| miR-181a | Reporter assay, mRNA/protein expression, functional assays | [64] | ||
| miR-487a | Reporter assay, mRNA/protein expression, functional assays | [65] | ||
| SLC6A4/SERT | miR-16 | Reporter assay, mRNA/protein expression, functional assays | [66,67,68] | |
| miR-15a | Reporter assay, protein expression | [68] | ||
| SLC7A5/LAT1 | miR-126 | Reporter assay, mRNA/protein expression, correlation | [69] | |
| SLC7A11 | miR-27a | Reporter assay, mRNA/protein expression, functional assays | [70] | |
| SLC12A2 | miR-384 a, -494, -1246 a | Reporter assay, mRNA expression | [71] | |
| SLC15A1/PEPT1 | miR-92b | Reporter assay, mRNA/protein expression, correlation, functional assays | [72] | |
| SLC16A1/MCT1 | miR-124 | Reporter assay, mRNA/protein expression, functional assays | [73,74] | |
| Nuclear Receptor | HNF4α | miR-24, -34a | Reporter assay, mRNA/protein expression, functional assays | [76,77] |
| miR-34a, -34c-5p, -449a | Reporter assay, mRNA/protein expression, functional assays | [78,79] | ||
| PXR | miR-148a | Reporter assay, protein expression | [80] | |
| VDR | miR-27b | Reporter assay, mRNA/protein expression | [23] | |
| miR-125b | Reporter assay, EMSA, protein expression | [30] | ||
| GR | miR-18, -124a | Reporter assay, protein expression, functional assays | [85] | |
| ESR1 | miR-206 | Reporter assay, mRNA/protein expression | [86] | |
| miR-221, -222 | Reporter assay, protein expression, functional assays | [87] | ||
| miR-22 | Reporter assay, mRNA/protein expression | [88,89] | ||
| miR-130a | Reporter assay, mRNA/protein expression | [90] | ||
| PPARα | miR-10b, -21, -27b | Reporter assay, mRNA/protein expression, correlation | [91,92] | |
| miR-506 | Reporter assay, mRNA/protein expression, functional assays | [93] | ||
| LXRα | miR-613 a | EMSA, reporter assay, mRNA/protein expression, functional assays | [94,95] | |
| miR-206 | Reporter assay, mRNA/protein expression, functional assays | [96] |
a MiRNAs that are not listed as bona fide miRNAs in MirGeneDB [5]. EMSA: electrophoresis mobility shift assay.