Table 4.
Organ weights of rats following injection of GO in the seven-day subchronic toxicity study.
Organ Weights | Sham | GO 2.5 mg/kg | GO 5 mg/kg | GO 10 mg/kg |
---|---|---|---|---|
Brain | ||||
Absolute organ weight (g) | 1.68 ± 0.04 | 1.72 ± 0.05 | 1.75 ± 0.06 | 1.68 ± 0.06 |
organ coefficient % | 1.30 ± 0.12 | 1.32 ± 0.12 | 1.34 ± 0.12 | 1.29 ± 0.16 |
Heart | ||||
Absolute organ weight (g) | 0.55 ± 0.05 | 0.48 ± 0.05 | 0.52 ± 0.04 | 0.5 ± 0.07 |
organ coefficient % | 0.43 ± 0.05 | 0.36 ± 0.05 | 0.37 ± 0.03 | 0.38 ± 0.03 |
Liver | ||||
Absolute organ weight (g) | 4.36 ± 0.14 | 4.37 ± 0.18 | 4.04 ± 0.37 | 3.83 ± 0.42 |
organ coefficient % | 3.33 ± 0.36 | 3.34 ± 0.39 | 3.03 ± 0.3 | 2.99 ± 0.09 |
Spleen | ||||
Absolute organ weight (g) | 0.38 ± 0.06 | 0.39 ± 0.05 | 0.44 ± 0.03 | 0.4 ± 0.04 |
organ coefficient % | 0.31 ± 0.06 | 0.28 ± 0.03 | 0.30 ± 0.03 | 0.31 ± 0.06 |
Lung | ||||
Absolute organ weight (g) | 0.84 ± 0.12 | 0.79 ± 0.04 | 0.82 ± 0.16 | 0.95 ± 0.18 |
organ coefficient % | 0.67 ± 0.08 | 0.58 ± 0.07 | 0.67 ± 0.06 | 0.71 ± 0.06 |
Kidney | ||||
Absolute organ weight (g) | 0.03 ± 0.009 | 0.04 ± 0.005 | 0.03 ± 0.005 | 0.031 ± 0.005 |
organ coefficient % | 0.86 ± 0.08 | 0.85 ± 0.09 | 0.82 ± 0.04 | 0.80 ± 0.03 |
Thymus gland | ||||
Absolute organ weight (g) | 0.26 ± 0.07 | 0.33 ± 0.043 | 0.32 ± 0.014 | 0.33 ± 0.038 |
organ coefficient % | 0.22 ± 0.05 | 0.27 ± 0.05 | 0.25 ± 0.02 | 0.25 ± 0.03 |
Adrenal gland (×100) | ||||
Absolute organ weight (g) | 3.23 ± 0.9 | 4.22 ± 0.52 | 3.08 ± 0.48 | 3.1 ± 0.47 |
organ coefficient % | 2.08 ± 0.45 | 2.49 ± 0.44 | 2.17 ± 0.41 | 2.17 ± 0.25 |
Prostate gland | ||||
Absolute organ weight (g) | 0.87 ± 0.04 | 0.81 ± 0.04 | 0.92 ± 0.16 | 0.95 ± 0.15 |
organ coefficient % | 0.08 ± 0.04 | 0.07 ± 0.02 | 0.07 ± 0.02 | 0.05 ± 0.02 |
Testis | ||||
Absolute organ weight (g) | 1.05 ± 0.26 | 1.19 ± 0.18 | 1.14 ± 0.19 | 1.11 ± 0.06 |
organ coefficient % | 0.86 ± 0.23 | 0.85 ± 0.09 | 0.88 ± 0.17 | 0.94 ± 0.14 |
Epididymis | ||||
Absolute organ weight (g) | 0.7 ± 0.077 | 0.77 ± 0.19 | 0.82 ± 0.17 | 0.79 ± 0.06 |
organ coefficient % | 0.57 ± 0.11 | 0.65 ± 0.15 | 0.64 ± 0.08 | 0.61 ± 0.03 |