Table 5.
Routine blood indexes of rats following injection of GO in the seven-day subchronic toxicity study.
| Parameter | Sham | GO 2.5 mg/kg | GO 5 mg/kg | GO 10 mg/kg |
|---|---|---|---|---|
| RBC (×1012/L) | 4.5 ± 0.1 | 4.7 ± 0.17 | 4.67 ± 0.23 | 4.36 ± 0.24 |
| HCT (%) | 33.3 ± 1.25 | 34.9 ± 1.6 | 33.68 ± 1.81 | 31.9 ± 1.67 |
| MCV (fL) | 75.75 ± 3.3 | 74.5 ± 2.08 | 72.25 ± 1.26 | 73.25 ± 1.89 |
| Hb (g/L) | 101.25 ± 2.99 | 105.75 ± 4.92 | 103.5 ± 4.65 | 97.5 ± 6.35 |
| MCH (pg) | 22.75 ± 0.96 | 22.5 ± 0.58 | 22.25 ± 0.5 | 22.5 ± 0.58 |
| MCHC (g/L) | 304 ± 3.56 | 303.25 ± 2.06 | 307 ± 4.08 | 306 ± 4.24 |
| WBC (×109/L) | 4.88 ± 0.79 | 6.75 ± 1.63 | 5.23 ± 0.59 | 5.68 ± 1.48 |
| LYM (×109/L) | 3.7 ± 0.76 | 5.5 ± 1.44 | 4 ± 0.88 | 4.03 ± 0.72 |
| LYM (%) | 75.6 ± 5.5 | 81.55 ± 4.9 | 75.38 ± 9.8 | 71.95 ± 6.65 |
| PLT (×109/L) | 1034.5 ± 57.36 | 1075.5 ± 78.8 | 1053.25 ± 76.5 | 964.25 ± 131.02 |
| PLT (%) | 0.51 ± 0.03 | 0.52 ± 0.04 | 0.5 ± 0.04 | 0.46 ± 0.07 |
| PT (s) | 15.28 ± 0.61 | 15.08 ± 0.53 | 15 ± 0.63 | 15.58 ± 0.71 |
| APPT (s) | 27.4 ± 3.69 | 24.6 ± 1.53 | 25.05 ± 1.63 | 23.6 ± 8.41 |
| TT (s) | 31.93 ± 5.81 | 27.5 ± 5.94 | 33.38 ± 7.63 | 22.65 ± 13.32 |
p > 0.05 compared with sham group, n = 8 rats, Mean ± SD; RBC: Red blood cells; HCT: Hematocrit; MCV: Mean red cell volume; Hb: Hemoglobin; MCH: Mean corpuscular hemoglobin; MCHC: Mean corpuscular hemoglobin concentration; WBC: White blood cells; LYM: Lymphocyte; PLT: Platelets; PT: Prothrombin time; APPT: Activated partial thromboplastin time; TT: Thrombin time.