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. 2016 Sep 17;94(11):1341–1348. doi: 10.1002/jnr.23804

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© 2016 The Authors. Journal of Neuroscience Research Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Schematic of contact‐dependent (2, 3) or secretory mechanisms (1, 4) by which oligodendrocytes could activate microglia. Secretion or exocytosis of accumulating metabolites, such as psychosine (1). Changes in membrane microdomains or membrane‐associated proteins recognized by microglia (2). Intracellular changes caused by GALC deficiency that affect membrane components, which activate microglia (3). Secretion of immune‐related molecules such as cytokines or DAMPs (4). Microglial self‐activation (5). DAMPs, danger associated molecular patterns; psy, psychosine.