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. 2016 Oct 28;240(4):397–409. doi: 10.1002/path.4808

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© 2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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PATH-4808-FIG-0003-c — Model of events contributing to fibrosis in lung disease. (A) The common view that persistent inflammatory responses contribute to fibrosis. (B) In response to injury and fibrotic events, fibroblasts migrate towards the site of injury, proliferate, and ultimately differentiate into myofibroblasts. These cells specialize in ECM production. (C) Several mesenchymal progenitor cells in the lung may be involved in fibrotic events and contribute to the fibroblast pool in lung fibrosis, including fibrocytes, MSCs, pericytes, and potentially other progenitors. Epithelial cells may contribute to the fibroblast pool through EMT. (D) Migration is influenced in a complex way by tissue stiffness.