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. 2016 Aug 15;18(12):1176–1190. doi: 10.1111/dom.12735

Figure 4.

Figure 4

Effects of MEDI0382 on body weight (A), food intake (B) and glucose tolerance (C) in male DIO mice after repeated daily s.c. administration of vehicle, MEDI0382 (10 or 30 nmol/kg) or liraglutide (40 nmol/kg) for 28 days. Glucose tolerance (IPGTT) was conducted by i.p. administration of glucose (1 g/kg) on day 21. Time 0 is immediately prior to glucose challenge. Insets show overall area under the curve (AUC) values for food intake (B) and blood glucose (C). Values are presented as mean (± SEM); n = 11‐12 mice/group. *p < .05; ***p < .001 compared to vehicle.