Table 1.
Association between the two types of MPO‐ANCA affinity and occurrences of NETs in MPO‐AAV patients. Thirty patients studied were classified as high‐and low‐affinity groups with smaller than 0.30 of IC50 and larger than 0.30 of IC50, respectively
| Renal findings | NET occurrences§ | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| M/F (Gender) | Age (mean ± SD) | MPO‐ANCA affinity (IC50)* (µg/mL) (mean ± SD) | MPO‐ANCA titre (EU) ** (median (interquatile range) | BVAS*** (mean ± SD) | eGFR (mL/min per 1.73 m2) (mean ± SD) | ****RPGN(%)/CRF†(%) | Histopatholo.‡(%) | Cit histone H3/MPO | PAD4/MPO | ||
| High affinity | |||||||||||
| (G1) | 7 / 8 | 70 ± 4 | 0.11 ± 0.04 | 513 | 15.6 ± 5.7 | 21.25 ± 23.06 | 73 / 27 | F | 33 | 8.5 ± 2.5 | 2.5 ± 0.5 |
| (n = 15) | (287–1680) | C | 40 | ||||||||
| M | 27 | ||||||||||
| S | 0 | ||||||||||
| Low affinity | |||||||||||
| (G2) | 7 / 8 | 66 ± 3 | 0.66 ± 0.24 | 622 | 9.2 ± 4.9 | 31.11 ± 22.23 | 27 / 73 | F | 13 | ||
| (n = 15) | (205–979) | C | 14 | 0.0 ± 0.5 | 0.0 ± 0.5 | ||||||
| M | 33 | ||||||||||
| S | 40 | ||||||||||
*
P < 0.001,
**
P = 0.330,
***
P = 0.002,
****
P = 0.002.
†
CRF, chronic renal failure; RPGN, rapidly progressive glomerulonephritits.
‡
C, crescentic; F, focal; M, mixed; S, sclerotic.
§
NET occurrences: mean numbers of signals double positive for citrullinated histone H3 and MPO or PAD4 and MPO concomitant with DNA per glomerular cross section; P‐values between high and low affinity groups.