Table 1.
Renal findings | NET occurrences§ | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
M/F (Gender) | Age (mean ± SD) | MPO‐ANCA affinity (IC50)* (µg/mL) (mean ± SD) | MPO‐ANCA titre (EU) ** (median (interquatile range) | BVAS*** (mean ± SD) | eGFR (mL/min per 1.73 m2) (mean ± SD) | ****RPGN(%)/CRF†(%) | Histopatholo.‡(%) | Cit histone H3/MPO | PAD4/MPO | ||
High affinity | |||||||||||
(G1) | 7 / 8 | 70 ± 4 | 0.11 ± 0.04 | 513 | 15.6 ± 5.7 | 21.25 ± 23.06 | 73 / 27 | F | 33 | 8.5 ± 2.5 | 2.5 ± 0.5 |
(n = 15) | (287–1680) | C | 40 | ||||||||
M | 27 | ||||||||||
S | 0 | ||||||||||
Low affinity | |||||||||||
(G2) | 7 / 8 | 66 ± 3 | 0.66 ± 0.24 | 622 | 9.2 ± 4.9 | 31.11 ± 22.23 | 27 / 73 | F | 13 | ||
(n = 15) | (205–979) | C | 14 | 0.0 ± 0.5 | 0.0 ± 0.5 | ||||||
M | 33 | ||||||||||
S | 40 |
P < 0.001,
P = 0.330,
P = 0.002,
P = 0.002.
CRF, chronic renal failure; RPGN, rapidly progressive glomerulonephritits.
C, crescentic; F, focal; M, mixed; S, sclerotic.
NET occurrences: mean numbers of signals double positive for citrullinated histone H3 and MPO or PAD4 and MPO concomitant with DNA per glomerular cross section; P‐values between high and low affinity groups.