. 2016 Sep 28;68(10):2527–2539. doi: 10.1002/art.39718

Table 2.

NVC covariables selected at the ULR analysis stage and carried forward to the MLR within‐bundle analysis in the DU history group^a

Variable	Summary statistics		ULR
Variable	Cases (n = 103)	Noncases (n = 365)	Parameter	Coefficient estimate (SE)	OR (95% CI)	P ^b	ROC AUC (95% CI)
Quantitative NVC characteristics (bundle 5)
Finger level: dominant hand, 4 individual fingers (sub‐bundle 5.5)^c
Index finger, mean ± SD/mm; n
No. of capillaries	3.9 ± 2.2; 89	4.5 ± 2.3; 325	Intercept	−0.7504 (0.2573)	0.879 (0.787–0.981)	0.022	0.603 (0.538–0.668)
No. of capillaries	3.9 ± 2.2; 89	4.5 ± 2.3; 325	Linear	−0.1294 (0.0564)	0.879 (0.787–0.981)	0.022	0.603 (0.538–0.668)
No. of microhemorrhages^d	0.1 ± 0.4; 89	0.2 ± 0.5; 325	Intercept	−1.2157 (0.1270)	0.592 (0.305–1.150)	0.122	0.552 (0.512–0.593)
No. of microhemorrhages^d	0.1 ± 0.4; 89	0.2 ± 0.5; 325	Linear	−0.5239 (0.3386)	0.592 (0.305–1.150)	0.122	0.552 (0.512–0.593)
Middle finger, mean ± SD/mm; n
No. of capillaries^d	3.8 ± 1.9; 97	4.7 ± 2.2; 339	Intercept	−0.3115 (0.2790)	0.801 (0.707–0.907)	<0.001	0.614 (0.553–0.674)
No. of capillaries^d	3.8 ± 1.9; 97	4.7 ± 2.2; 339	Linear	−0.2217 (0.0634)	0.801 (0.707–0.907)	<0.001	0.614 (0.553–0.674)
No. of microhemorrhages	0.2 ± 0.8; 97	0.3 ± 0.6; 339	Intercept	−1.1172 (0.1247)	^e	0.007	0.565 (0.524–0.605)
			Linear	−1.6839 (0.5904)
			Quadratic	0.5243 (0.1933)
No. of neoangiogeneses^d	0.6 ± 0.9; 97	0.4 ± 0.8; 339	Intercept	−1.4030 (0.1390)	1.326 (1.024–1.718)	0.032	0.558 (0.498–0.617)
No. of neoangiogeneses^d	0.6 ± 0.9; 97	0.4 ± 0.8; 339	Linear	0.2823 (0.1319)	1.326 (1.024–1.718)	0.032	0.558 (0.498–0.617)
Ring finger, mean ± SD/mm; n
No. of capillaries	4.2 ± 2.1; 99	4.6 ± 2.1; 343	Intercept	−0.7917 (0.2677)	0.902 (0.807–1.009)	0.070	0.564 (0.500–0.629)
No. of capillaries	4.2 ± 2.1; 99	4.6 ± 2.1; 343	Linear	−0.1031 (0.0570)	0.902 (0.807–1.009)	0.070	0.564 (0.500–0.629)
Little finger, mean ± SD/mm; n
No. of capillaries	4.1 ± 1.8; 97	5.0 ± 2.1; 347	Intercept	−0.3062 (0.2920)	0.808 (0.715–0.913)	<0.001	0.620 (0.558–0.681)
No. of capillaries	4.1 ± 1.8; 97	5.0 ± 2.1; 347	Linear	−0.2137 (0.0624)	0.808 (0.715–0.913)	<0.001	0.620 (0.558–0.681)
Qualitative NVC characteristics (variable not included in a bundle)^f
NVC pattern at enrollment, n/N (%)
Normal	0/103 (0.0)	4/363 (1.1)					0.597 (0.548–0.647)
Early	4/103 (3.9)	40/363 (11.0)
Active	25/103 (24.3)	123/363 (33.9)	Intercept	−2.3972 (0.5221)	2.234 (0.736–6.779)^g	0.156^g
Active	25/103 (24.3)	123/363 (33.9)	Factor	0.8039 (0.5663)	2.234 (0.736–6.779)^g	0.156^g
Late	74/103 (71.8)	196/363 (54.0)	Factor	1.4231 (0.5396)	4.150 (1.441–11.950)^h	0.008^h

Data are summary statistics of nailfold videocapillaroscopy (NVC) covariables selected and carried forward to the multivariable logistic regression (MLR) within‐bundle analysis in patients who developed (cases) and those who did not develop (noncases) a digital ulcer (DU) during the observation period. Quantitative NVC characteristics carried forward to the MLR within‐bundle and across‐bundles analyses for sub‐bundles 5.1–5.4 and sub‐bundle 5.6 are shown in Supplementary Table 5 (in section 3 of the Supplementary Materials, available on the Arthritis & Rheumatology web site at http://onlinelibrary.wiley.com/doi/10.1002/art.39718/abstract). ULR = univariable logistic regression; 95% CI = 95% confidence interval.

By Wald's chi‐square test.

The mean value at the finger level is the mean count per measurement from 2 capillaroscopic images.

Variable was also carried forward to the MLR across‐bundles analysis.

The odds ratio (OR) is not given since the functional relationship is quadratic. The associated P value and receiver operating characteristic (ROC) area under the curve (AUC) are quadratic terms.

Used in an alternative final model as a “surrogate” for NVC quantitative variables.

Active versus normal/early pattern.

Late versus normal/early pattern.