Table 3.
Medication use and relationship to DU disease severitya
| Medication class | Summary statistics | P for association with DU disease severity | ||
|---|---|---|---|---|
| No. (%) of cases (n = 103) | No. (%) of noncases (n = 365) | No. of DUs (n = 468)b | Hospitalization due to DUs (n = 468)c | |
| At least 1 medication class | 97 (94.2) | 343 (94.0) | – | – |
| Vasoactive medication | ||||
| Endothelin receptor antagonists | 43 (41.7)d | 113 (31.0) | 0.0251 | 0.0856 |
| Phosphodiesterase 5 inhibitors | 15 (14.6) | 31 (8.5) | 0.0088 | 0.8604 |
| Prostanoids, including intravenous formulation | 54 (52.4)d | 140 (38.4) | 0.3159 | <0.0001 |
| Angiotensin‐converting enzyme inhibitors, angiotensin receptor blockers | 27 (26.2) | 112 (30.7) | 0.3283 | 0.5535 |
| Calcium‐channel blockers | 57 (55.3) | 206 (56.4) | 0.1044 | 0.0553 |
| Selective serotonin reuptake inhibitors | 11 (10.7) | 39 (10.7) | 0.1935 | 0.0192 |
| Nitrates | 3 (2.9) | 15 (4.1) | 0.9737 | 0.7506 |
| Statins | 10 (9.7)d | 69 (18.9) | 0.0568 | 0.1097 |
| Other vasodilators | 10 (9.7) | 53 (14.5) | 0.3635 | 0.1534 |
| Platelet aggregation inhibitors | 39 (37.9) | 163 (44.7) | 0.1265 | 0.2490 |
| Immunosuppressants | 53 (51.5)d | 139 (38.1) | 0.1989 | 0.7551 |
a
Includes ongoing medication use and medication use within 3 months prior to and at enrollment. DU = digital ulcer.
b
By Cochran‐Armitage trend test.
c
By chi‐square test.
d
P < 0.05 versus noncases, by chi‐square test and Fisher's exact test.