Table 3.

Similarity index for ten most similar symptom pairs for social media and research study groups (social media n = 50,426; research study n = 653)

Social media group		Research study group T1 moderate and severe symptoms		Research study group T2 severe symptoms only
Symptom pair	Similaritya	Symptom pair	Similarity	Symptom pair	Similarity
General aches–headaches	0.355	Hot flashes–night sweats	0.872	Loss of interest in work–lowered  work performance	0.763
Hot flashes–mood changes	0.331	Depressed–mood changes	0.737	Hot flashes–night sweats	0.751
Constipation–diarrhea	0.246	Fatigue–restless sleep	0.722	General aches–muscle pains	0.652
Hot flashes–night sweats	0.204	General aches–joint pains	0.710	Joint pains–muscle pains	0.652
Difficulty concentrating–  sleeping too much	0.183	Decreased efficiency–lowered work  performance	0.709	Decreased efficiency–lowered work  performance	0.624
Diarrhea–nausea	0.177	Loss of interest in work–lowered  work performance	0.704	General aches–joint pains	0.621
Bloating–constipation	0.156	Decreased efficiency–loss of  interest in work	0.702	Depressed–mood changes	0.556
Hot flashes–vaginal dryness	0.143	Decreased efficiency–difficulty  concentrating	0.659	Decreased efficiency–loss of  interest in work	0.462
Fatigue–Nausea	0.138	General aches–muscle pains	0.652	Joint pains–neck-skull aches	0.460
Bloating–Abdominal Pain	0.138	Joint pains–muscle pains	0.637	Fatigue–lowered work performance	0.457

^aSimilarity between symptoms i and j is defined as co-occurrence (i, j)/square root (occurrence (i) × occurrence (j)); higher value represents greater similarity