Table 1.
Baseline characteristics of study participants
| Characteristics | Hydroxyzine Group | Placebo Group | Blinded Hydroxyzine/Placebo Group | |||
|---|---|---|---|---|---|---|
| Age, mean (SD), yr. | 31.5 (6.4) | 30.8 (6.1) | 31.8 (7.2) | |||
| Sex, no. (%) | ||||||
| Female | 50 (32) | 56 (35) | 58 (36) | |||
| Male | 106 (68) | 102 (65) | 101 (64) | |||
| Completed education, no. (%) | ||||||
| High school | 36 (23) | 38 (24) | 30 (19) | |||
| College | 85 (55) | 72 (46) | 88 (55) | |||
| University | 35 (22) | 48 (30) | 41 (26) | |||
| Occupational status, no. (%) | ||||||
| Professional, technical, managerial | 32 (22) | 45 (29) | 37 (24) | |||
| Clerical, sales | 1 (1) | 0 (0) | 2 (1) | |||
| Service | 107 (72) | 99 (63) | 101 (66) | |||
| Agricultural, fishery, related | 0 (0) | 1 (1) | 2 (1) | |||
| House wife | 0 (0) | 1 (1) | 2 (1) | |||
| Student | 5 (3) | 6 (4) | 7 (5) | |||
| Unemployed | 4 (3) | 4 (3) | 3 (2) | |||
| Told hydroxyzine | Told placebo | Told placebo | Told hydroxyzine | Received hydroxyzine | Received placebo | |
| Drowsiness level, mean (SD), mma | 4.5 (6.0) | 6.3 (10.1) | 4.7 (6.6) | 5.1 (8.5) | 4.9 (7.3) | 4.6 (8.0) |
| Mouth-dryness level, mean (SD), mm a | 5.9 (9.5) | 8.5 (15.5) | 6.2 (10.2) | 6.1 (11.5) | 5.5 (8.8) | 5.7 (11.6) |
| Nausea level, mean (SD), mm a | 2.8 (4.4) | 3.0 (5.8) | 2.9 (4.9) | 3.5 (7.4) | 2.3 (5.2) | 3.0 (6.4) |
| Itchiness level, mean (SD), mm a | 2.8 (3.8) | 2.6 (4.3) | 2.8 (4.5) | 3.1 (5.3) | 2.7 (4.5) | 2.7 (4.4) |
Hydroxyzine group (group-1, n = 156): received 25 mg hydroxyzine twice and told its hydroxyzine on one time and placebo on the other, in a randomized crossover design. Placebo group (group-2, n = 158): received placebo twice and told its placebo on one time and 25 mg hydroxyzine on the other, in a randomized crossover design. Blinded hydroxyzine/placebo group (group-3, n = 159): received 25 mg hydroxyzine and placebo in a randomized single-blinded crossover design. Numbers may not sum up to group totals because of missing data and percentages may not add to 100% because of rounding
a Measured on 100 mm visual analog scale