Figure 2. Representation of the personalized medicine concept in CPVT investigation. The process begins with obtaining skin or hair follicles biopsy from patient followed by reprograming procedure to generate iPSC cell-line holding the ability of differentiating into functional cardiomyocytes. To evaluate the effect of different anti-arrhythmic drugs on patient specific iPSC-CMs the scheme continues with electrophysiology and calcium-contraction study, involving external β-adrenergic stimulation resulting in arrhythmia represented as DADs. Subsequently the model allows the assessment of different anti-arrhythmic drugs for elimination of in vitro arrhythmias. Prominent agents should be tested for their effect within the patient.