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. 2016 Dec;148(6):489–501. doi: 10.1085/jgp.201611684

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© 2016 Jin et al.

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Figure 2. — General model predictions. (A) Pseudocolored images showing tracer concentration (C_B/C_B^o) at time = 60, 600, and 1,500 s after a step increase in para-arterial tracer concentration for ΔP = 1 mmHg, P_f = 0.04 cm/s, and D = 10⁻¹⁰ m²/s. (B) C_B/C_B^o and P/P_o profiles from para-arterial to paravenous space at the indicated times. (C, left) Pseudocolored images showing tracer solute accumulation in ECS after a step increase in para-arterial tracer concentration for para-arterial to paravenous pressure differences ΔP of 0 mmHg (diffusion alone) or 1 or 10 mmHg. Parameters: P_f = 0.04 cm/s and D = 10⁻¹⁰ m²/s. (right, top) Kinetics of tracer solute accumulation in ECS for the indicated ΔP. (right, bottom) Steady-state tracer solute transfer from para-arterial to paravenous spaces for fixed concentration (C_B = 0) at the paravenous space.