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Systolic, mean, and diastolic blood pressure (BP). Hyperhomocysteinemic (HHcy) mice had significantly higher systolic, mean, and diastolic BP and mice with combined genetic HHcy and TLR-4 mutation (CBS+/−/C3H) had significantly lower systolic, mean, and diastolic BP. Values are means ± SE (n = 10). *P < 0.05, WT vs. CBS+/−. #P < 0.05, WT vs. C3H. §P < 0.05, CBS+/− vs. CBS+/−/C3H.
