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A and B: immunohistochemistry (IHC) for TLR-4 and TNF-α. IHC showed increased intensity of TLR-4 and TNF-α in the SMA of CBS+/− mice. TLR-4 and TNF-α intensities were reduced in mice with combined genetic HHcy and TLR-4 mutation. Values are means ± SE (n = 4). *P < 0.05 vs. WT. #P < 0.05 vs. CBS+/−.
