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. 2016 Aug 3;311(4):C596–C606. doi: 10.1152/ajpcell.00088.2016

Fig. 7.

Fig. 7.

TLR-4 mutation mitigates HHcy-induced DNA fragmentation. TUNEL assay was used to evaluate DNA fragmentation (arrows) in the SMA. DNA fragmentation was significantly augmented in the SMA of CBS+/− mice compared with WT and C3H mice. TUNEL-positive cell count was reduced in the SMA of CBS+/−/C3H mice compared with CBS+/− mice. ctr, Control. Values are means ± SE (n = 4). *P < 0.05 vs. WT. #P < 0.05 vs. CBS+/−.