Table 2. HRQoL best response for the overall population and by BRCA status.

	Overall population, n (%)		BRCAm, n (%)		gBRCAm, n (%)
	Olaparib	Placebo	Olaparib	Placebo	Olaparib	Placebo
TOI	n=115	n=111	n=64	n=53	n=45	n=37
Baseline score, mean (s.d.)	81.7 (11.8)	81.5 (11.6)	79.9 (12.1)	79.5 (12.1)	79.5 (12.3)	81.0 (11.0)
Improved	23 (20.0)	20 (18.0)	16 (25.0)	10 (18.9)	12 (26.7)	3 (8.1)
No change	72 (62.6)	67 (60.4)	38 (59.4)	30 (56.6)	27 (60.0)	22 (59.5)
Worsened	16 (13.9)	20 (18.0)	7 (10.9)	10 (18.9)	4 (8.9)	9 (24.3)
Non-evaluable	4 (3.5)	4 (3.6)	3 (4.7)	3 (5.7)	2 (4.4)	3 (8.1)
FOSI	n=117	n=115	n=66	n=56	n=46	n=39
Baseline score, mean (s.d.)	26.1 (3.4)	25.4 (3.8)	25.9 (3.4)	24.8 (4.1)	25.8 (3.3)	25.1 (4.1)
Improved	20 (17.1)	17 (14.8)	14 (21.2)	9 (16.1)	12 (26.1)	5 (12.8)
No change	74 (63.2)	74 (64.3)	39 (59.1)	36 (64.3)	26 (56.5)	23 (59.0)
Worsened	20 (17.1)	21 (18.3)	11 (16.7)	9 (16.1)	6 (13.0)	9 (23.1)
Non-evaluable	3 (2.6)	3 (2.6)	2 (3.0)	2 (3.6)	2 (4.3)	2 (5.1)
FACT-O	n=114	n=111	n=63	n=53	n=45	n=37
Baseline score, mean (s.d.)	121.9 (17.3)	119.7 (17.4)	118.9 (18.1)	115.9 (18.9)	119.5 (18.5)	118.6 (17.2)
Improved	24 (21.1)	21 (18.9)	17 (27.0)	11 (20.8)	13 (28.9)	4 (10.8)
No change	68 (59.6)	63 (56.8)	35 (55.6)	26 (49.1)	25 (55.6)	19 (51.4)
Worsened	20 (17.5)	24 (21.6)	10 (15.9)	14 (26.4)	6 (13.3)	12 (32.4)
Non-evaluable	2 (1.8)	3 (2.7)	1 (1.6)	2 (3.8)	1 (2.2)	2 (5.4)
Nausea	n=115	n=113	n=64	n=54	n=44	n=37
Improved	5 (4.3)	11 (9.7)	0 (0)	6 (11.1)	0 (0)	4 (10.8)
No change	69 (60.0)	77 (68.1)	43 (67.2)	38 (70.4)	31 (70.5)	24 (64.9)
Worsened	37 (32.2)	19 (16.8)	18 (28.1)	5 (9.3)	12 (27.3)	4 (10.8)
Non-evaluable	4 (3.5)	6 (5.3)	3 (4.7)	5 (9.3)	1 (2.3)	5 (13.5)
Vomiting	n=115	n=111	n=65	n=54	n=46	n=38
Improved	6 (5.2)	5 (4.5)	2 (3.1)	2 (3.7)	2 (4.3)	1 (2.6)
No change	95 (82.6)	94 (84.7)	54 (83.1)	45 (83.3)	38 (82.6)	31 (81.6)
Worsened	7 (6.1)	6 (5.4)	3 (4.6)	3 (5.6)	3 (6.5)	2 (5.3)
Non-evaluable	7 (6.1)	6 (5.4)	6 (9.2)	4 (7.4)	3 (6.5)	4 (10.5)