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. 2016 Nov 3;115(11):1367–1378. doi: 10.1038/bjc.2016.362

Figure 3.

Figure 3

miR-214 suppresses invasion and metastasis of CRC by targeting MED19. (A and B) Effect of miR-214 inhibitor on the invasion of LOVO and HT-29 cells by Boyden chamber. Morphologic comparison of cells penetrating the artificial basement membrane was shown. Scale bars represent 50 μm. (C and D) Effects of miR-214 and miR-214/MED19 on cell invasion of SW480 and HCT116 cells by Boyden chamber. Morphologic comparison of cells penetrating the artificial basement membrane was shown. Scale bars represent 50 μm. (E) SW480/Mock, SW480/miR-214 and SW480/miR-214/MED19 cells were injected into the tail vein of nude mice. Yellow arrows in top panels point at lung metastatic nodules. Scale bars in bottom panels represent 500 μm. (F) The number of lung metastatic nodules per mouse was counted under the microscope. *P<0.05, **P<0.01. Data represent the mean±SD.