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. 2016 Nov 3;115(11):1367–1378. doi: 10.1038/bjc.2016.362

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Copyright © 2016 Cancer Research UK

From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Promoter hypermethylation contributes to the transcriptional silencing of miR-214 in CRC. (A) The analysis results of GEO showed that the degree of CpG Island methylation in CRC was higher than that in normal mucosa. (B) Bisulphite genomic-sequencing analysis of the CpG island of DNM3 promoter in paired CRC tissue. (C) The relationship between the expression of miR-214 and the degree of CpG Island methylation in eight cases of CRC tissues and corresponding normal mucosa. miR-214 expression was determined by real-time PCR. The methylation percentage was calculated using the BSP results from B. *P<0.05, **P<0.01. Data represent the mean±SD.