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. 2016 Nov 3;115(11):1367–1378. doi: 10.1038/bjc.2016.362

Figure 6.

Figure 6

FOXD3 upregulates miR-214 expression and suppresses CRC invasion and metastasis. (A) Effects of shFOXD3 and shFOXD3/miR-214 on cell invasion of SW480 and SW620 cells by Boyden chamber. Morphologic comparison of cells penetrating the artificial basement membrane was shown. Scale bars represent 50 μm. (B) The number of invaded SW480 and SW620 cells was measured under the microscope. (C) SW620/NC, SW620/shFOXD3 and SW620/shFOXD3/miR-214 cells were injected into the tail vein of nude mice. Yellow arrows in top panels point at lung metastatic nodules. Scale bars in bottom panels represent 500 μm. (D) The number of lung metastatic nodules per mouse was counted under the microscope. *P<0.05, **P<0.01. Data represent the mean±SD.