Table 5. HRs (95% CI) for CRC and subsites by quintiles (Q) of PC3 score and for 1s.d. increase in PC3 score.
| Q1 | Q2 | Q3 | Q4 | Q5 | P-trend | HR (95% CI) per 1 s.d. increase | P-value HR continuous for 1 s.d. increase | |
|---|---|---|---|---|---|---|---|---|
|
Colorectum | ||||||||
| N cases | 790 | 899 | 937 | 1003 | 888 | |||
| Basica | 1.00 (Ref) | 1.03 (0.94–1.14) | 1.02 (0.92–1.13) | 1.07 (0.97–1.19) | 0.99 (0.89–1.12) | 0.920 | 1.00 (0.97–1.04) | 0.817 |
| Multivariableb | 1.00 (Ref) | 1.03 (0.93–1.13) | 1.01 (0.91–1.12) | 1.06 (0.96–1.18) | 0.98 (0.88–1.10) | 0.935 | 1.00 (0.96–1.04) | 0.99 |
|
Colon | ||||||||
| N cases | 523 | 553 | 606 | 644 | 543 | |||
| Basica | 1.00 (Ref) | 0.99 (0.88–1.12) | 1.04 (0.92–1.18) | 1.09 (0.95–1.24) | 0.95 (0.83–1.10) | 0.854 | 0.98 (0.95–1.04) | 0.722 |
| Multivariableb | 1.00 (Ref) | 0.98 (0.87–1.12) | 1.04 (0.91–1.18) | 1.08 (0.95–1.23) | 0.94 (0.82–1.09) | 0.762 | 0.99 (0.94–1.04) | 0.608 |
|
Colon, proximal | ||||||||
| N cases | 199 | 258 | 271 | 314 | 256 | |||
| Basica | 1.00 (Ref) | 1.16 (0.96–1.40) | 1.12 (0.92–1.36) | 1.23 (1.01–1.50) | 1.05 (0.84–1.30) | 0.626 | 0.99 (0.92–1.06) | 0.752 |
| Multivariableb | 1.00 (Ref) | 1.15 (0.95–1.40) | 1.12 (0.92–1.36) | 1.23 (1.00–1.50) | 1.05 (0.84–1.31) | 0.594 | 0.99 (0.92–1.06) | 0.771 |
|
Colon, distal | ||||||||
| N cases | 241 | 234 | 276 | 273 | 242 | |||
| Basica | 1.00 (Ref) | 0.92 (0.77–1.11) | 1.04 (0.87–1.26) | 1.05 (0.86–1.27) | 0.95 (0.77–1.18) | 0.941 | 1.01 (0.94–1.08) | 0.849 |
| Multivariableb | 1.00 (Ref) | 0.91 (0.76–1.10) | 1.03 (0.86–1.24) | 1.02 (0.84–1.25) | 0.93 (0.75–1.15) | 0.768 | 1.00 (0.93–1.07) | 0.94 |
|
Rectum | ||||||||
| N cases | 267 | 346 | 331 | 359 | 345 | |||
| Basica | 1.00 (Ref) | 1.11 (0.94–1.31) | 0.98 (0.83–1.17) | 1.05 (0.89–1.29) | 1.07 (0.89–1.29) | 0.681 | 1.03 (0.96–1.09) | 0.40 |
| Multivariableb | 1.00 (Ref) | 1.10 (0.94–1.30) | 0.97 (0.82–1.16) | 1.04 (0.87–1.24) | 1.05 (0.87–1.27) | 0.799 | 1.02 (0.96–1.09) | 0.515 |
Abbreviations: CI=confidence interval; CRC=colorectal cancer; HR=hazard ratio; PC=principal component; Ref=reference.
a
Basic model: Cox regression adjusted for total energy intake (log-transformed continuous variable) and for each score, and stratified by age (1-year categories), sex and centre.
b
Multivariable model: Cox regression adjusted for total energy intake (log-transformed continuous variable), alcohol (log-transformed continuous variable), smoking status (never, former, smoker, unknown), height (tertiles), weight (tertiles), physical activity level (inactive, moderately inactive, moderately active, active, missing) and for each score, and stratified by age (1-year categories), sex and centre.