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. Author manuscript; available in PMC: 2017 Nov 15.
Published in final edited form as: J Affect Disord. 2016 Jul 1;205:144–153. doi: 10.1016/j.jad.2016.03.074

Figure 2.

Figure 2

SPM regression analysis testing group, sleep duration, and group* sleep duration interaction as predictors of VS connectivity to win-control within the bilateral prefrontal cingulo-insular ROI mask. (A) Significant effect of group status on VS connectivity with the left posterior insula: k=59, peak voxel MNI xyz= [−42, −4, −5], t42=3.77, p<.001. (B) Extracted VS-Left posterior insula connectivity estimates displaying a significant difference between groups; means and standard error bars are presented, R2 represents variance explained for the overall regression. (C) Significant group*sleep duration interaction for VS connectivity with the left anterior insula/VLPFC: k=89, peak voxel MNI xyz= [−36, 8, −11], t42=3.11, p=.001. (D) Extracted VS-Left anterior insula/VLPFC connectivity estimates plotted versus sleep duration for group*sleep duration interaction, trend lines indicate simple slopes for each group, R2 represents variance explained for the overall regression. OBP=offspring of bipolar parents; OCP=offspring of control parents; VS=ventral striatum; VLPFC=ventrolateral prefrontal cortex.