Table I.

Lung pathology most commonly associated with primary antibody deficiency.

Pathology	Description
Non-necrotizing granulomatous inflammation	Inflammation characterized by circumscribed organized collections of macrophages (histiocytes) +/− giant cells. Non-necrotizing granulomas lack areas of central necrosis and may be a feature of many diseases both infectious and non-infectious.
Organizing pneumonia	Non-specific response to lung injury characterized by organizing fibroblastic tissue within alveolar spaces known as Masson bodies.
Benign lymphoproliferative lung disease
Nodular lymphoid hyperplasia	Well-circumscribed area of benign lymphoid hyperplasia effacing the lung parenchyma with well-demarcated follicles. The process is polyclonal and the relationship to lymphoma is unclear.
Follicular bronchiolitis	Lymphoid hyperplasia around airways with minimal involvement of the alveolar septa.
Lymphocytic interstitial pneumonia (LIP)	Thought to represent part of a spectrum of pulmonary lymphoid hyperplasia with follicular bronchiolitis but is characterized by lymphocytes in the interstitium expanding the alveolar septum. May contain non-necrotizing granulomatous inflammation. Organizing pneumonia is infrequent.
Granulomatous lymphocytic interstitial lung disease (GLILD)	Similar to LIP, but has more frequent, larger granulomas and large areas of organizing pneumonia are often present.