Table III.

Clinical and radiological features differentiating CVID ILD and sarcoidosis.

Clinical Feature	CVID ILD	Sarcoidosis
Low serum IgG	↑ ↑ ↑	↓ ↓ ↓
Autoimmune cytopenias (AIHA, ITP)	↑ ↑ ↑	↓ ↓ ↓
Splenomegaly	↑ ↑ ↑	↓ ↓ ↓
Nodular regenerative hyperplasia of the liver	↑ ↑ ↑	↓ ↓ ↓
Lymphocytic interstitial pneumonia	↑ ↑ ↑	↓ ↓ ↓
Follicular bronchiolitis	↑ ↑ ↑	↓ ↓ ↓
Recurrent infection	↑ ↑ ↑	↓ ↓ ↓
High BAL CD4:CD8 ratio	↓ ↓ ↓	↑ ↑ ↑
Low percentage of IgM-IgD-CD27+ memory B cells	↑ ↑ ↑	↓ ↓ ↓
Radiological Feature
Nodule size	large (>1 cm is common)	small (>1 cm is uncommon)
Nodule location	random distribution	apical lung zones, perilymphatic
Associated with bronchiectasis	↑ ↑ ↑	↓ ↓ ↓

↑↑↑ = increased likelihood

↓↓↓ = decreased likelihood

AIHA = autoimmune hemolytic anemia

BAL = bronchoalveolar lavage

ITP = immune thrombocytopenic purpura