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The cargo release by Arl2 and Arl3. Left panel; crystal structures of PDE6δ in complex with farnesyl peptide (PDB code: 3T5I) and Unc119 in complex with laurylated peptide (PDB code: 3RBQ). Middle panel; the binding of Arl2/3 to the carrier proteins PDE6δ and Unc119 result in the release of the lipid moiety. Right panel; the N-terminal helix of Arl3 and Arl2 display different conformation in the complex with the carrier proteins.
