Table 4. Association of GSTO1*C or APOE4 with the MCI classification based either on MMSE or the CERAD composite score (49 MCI patients, 113 controls).
| Test | SNP | B(SE) | Odds ratio (95% CI) | Sign. |
|---|---|---|---|---|
| MMSE | APOE4 (rs429358) | 0.437 (0.384) | 1.6 (0.7 - 3.3) | 0.255 |
| GSTO1*C (rs4925) | 0.397 (0.307) | 1.5 (0.8 - 2.7) | 0.196 | |
| CERAD | APOE4 (rs429358) | 1.128 (0.386) | 3.1 (1.5 - 6.6) | 0.004 |
| GSTO1*C (rs4925) | 0.636 (0.317) | 1.9 (1.02 - 3.5) | 0.045 |
Binary logistic regression analyses comparing controls and MCI patients that had been assigned either on the basis of the MMSE score (Methods) or the CERAD composite score (Table 3) were performed on the APOE4 allele or the GSTO1*C allele (rs4925). The genetic markers APOE4 and GSTO1*C are only significantly associated with the CERAD composite score-based classification (lower panel).
Abbreviations: B…Beta value, SE…standard error, CI… confidence interval, Sign. … significance