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. 2016 Jun 14;7(26):39162–39170. doi: 10.18632/oncotarget.10043

Figure 2. The NR4A1 gene was epigenetically regulated in the insulin signaling pathway.

Figure 2

A. 293T cells were transfected with the pcDNA vector or pcDNA-NR4A1 for 48 h, and the effects of NR4A1 overexpression on DNMT1 inhibition and induction of insulin receptor (IR) overexpression were analyzed. B. RIN-m5F cells were transfected with NR4A1 for 48 h, and the effects of NR4A1 overexpression on DNMT1 inhibition and induction of IR expression were analyzed. C. Effects of NR4A1 knockdown by shRNA and treatment with ATA in 293T cells. D. Effects of NR4A1 knockdown by shRNA and treatment with ATA in RIN-m5F cells.