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. 2016 May 9;7(26):39184–39196. doi: 10.18632/oncotarget.9258

Figure 1. Genomic organization of the human PRRT2 gene and the distribution of the PRRT2 mutations identified in Taiwanese PKD patients.

Figure 1

The genomic organization of human PRRT2 gene and the distribution of the seven PRRT2 mutations identified in Taiwanese PKD patients are illustrated in the upper panel. The predicted domains of the PRRT2 protein are shown in the lower panel. Six of the PRRT2 truncating mutations are localized in the predicted extracellular domain (amino acids 1-268), and five are clustered within or around the proline-rich domain (the red region).