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. 2016 May 9;7(26):39184–39196. doi: 10.18632/oncotarget.9258

Figure 4. Subcellular localization of PKD-related PRRT2 mutations in cultured HEK293T cells.

Figure 4

The six prematurely truncating Prrt2 mutants (P91QfsX, E199X, S202HfsX, R217EfsX, E217PfsX and R240X) were retained in the cytoplasm and failed to be properly transported to the membrane. Some faint signal from the p.P91QfsX, p.E199X and p.S202HfsX Prrt2 mutant proteins could be found in the nucleus. The missense R308C mutant protein had a membrane localization similar to the pattern for WT-Prrt2. Scale bar = 10 μm.