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. 2016 Jun 14;7(26):39197–39206. doi: 10.18632/oncotarget.10049

Table 1. Clinicopathological summary of endometrial papillary proliferations.

Case Clinical feature Histopathological feature
Age MP HRT Previousgynecologicalhistory Clinicalpresentation Currentstatus Type ofspecimen Pattern ofpapillaryproliferation Volume ofpapillaryproliferation Metaplasticepithelialchange Relation withEM hyperplasia or carcinoma
1 57 Yes No Cervical HSIL No symptom NED Hysterectomy Simple <10% of entire EM M, C, E, P No
2 65 Yes No No Vaginal bleeding, EM polyp NED Curettage Complex 80% of EM polyp M, E Subsequent atypical hyperplasia/EIN in hysterectomy specimen (after 4 months)
3 64 Yes Yes No Vaginal bleeding, Thickened EM NED Curettage Simple <10% of entire EM M, C, E Subsequent hyperplasia without atypia in hysterectomy specimen (after 3 months)
4 70 Yes No EM hyperplasia without atypia Vaginal spotting, Thickened EM NED Hysterectomy Simple <10% of entire EM M, E Coexistent well-differentiated EM carcinoma in hysterectomy specimen

C: ciliated cell metaplasia, E: eosinophilic cell change, EIN: endometrioid intraepithelial neoplasia, EM: endometrium, HRT: hormone replacement therapy, HSIL: high-grade squamous intraepithelial lesion, M: mucinous metaplasia, MP: menopause, NED: no evidence of disease, P: papillary syncytial metaplasia.