Table 6. p62 cytoplasmic/p62 nuclear classification was shown to be an independent prognostic parameter in a multivariate analysis encompassing pT category, pN category, absence or presence of distant metastasis, lymphatic invasion and perineural invasion as well as grading.
| parameter | HR | 95% confidence interval | p-value | |
|---|---|---|---|---|
| min | max | |||
| pT category pT1 vs pT2 vs pT3 vs pT4 |
1.505 | 0.916 | 2.472 | 0.106 |
| pN category pN0 vs pN1 vs pN2 vs pN3 |
1.396 | 0.985 | 1.977 | 0.061 |
| distant metastases absent vs present |
1.684 | 0.464 | 6.110 | 0.428 |
| lymphatic invasion absent vs present |
1.021 | 0.374 | 2.783 | 0.968 |
| perineural invasion absent vs present |
0.502 | 0.211 | 1.195 | 0.119 |
| Grading G1 vs G2 vs G3 |
1.584 | 0.935 | 2.685 | 0.087 |
| p62 cyto/p62 nucl LL vs mixed/HH |
0.561 | 0.329 | 0.956 | 0.033 |
Statistically significant p-values are shown in bold. HR – Hazard Ratio