Figure 2. Screen overview and top hits.

(A) Overview of the screening and hit selection process. (B) Validation of selected hits with a 3-thio-1,2,4-triazole core. The names and structures of these compounds are listed in Table 1. (C–D) Dose-response analysis for YUKA1 (C) and YUKA2 (D). Data are representative of at least four independent experiments performed in triplicate. Data points and bars in B-D indicate mean ± SEM.