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. 2016 May 23;7(26):39980–39995. doi: 10.18632/oncotarget.9556

Figure 4. Progranulin targeting modulates invasion and anchorage-independent growth of T24T urothelial cancer cells.

Figure 4

(A) Parental (P), shScr-transfected (Scr) control and Progranulin-depleted (shPGRN) T24T cells were assessed for invasive ability through Matrigel-coated transwells as described in Materials and Methods. Data are the average of three independent experiments ± SD. ***P < 0.001. (B) Anchorage-independent growth was measured by colony formation in soft-agar as described IN Materials and Methods. Colonies >150 μM were counted. The experiment is the average of three independent experiments run in duplicates ± SD. ***P < 0.001.