Table 4. LC50 concentrations for cisplatin, Nutlin-3 and RG7388 for the panel of ovarian cancer cell lines of varying TP53 status.
| Cell line | TP53 status | Cisplatin (μM) | Nutlin-3 (μM) | RG7388 (μM) |
|---|---|---|---|---|
| A2780 | Wild-type | 0.42 ± 0.0003 | 1.65 ± 0.71 | 0.14 ± 0.03 |
| IGROV-1 | Wild-type | 0.82 ± 0.06 | 11 ± 2.08 | 0.67 ± 0.15 |
| OAW42 | Wild-type | 0.28 ± 0.01 | 6.25 ± 0.50 | 0.15 ± 0.04 |
| CP70 | Mutant | 3.39 ± 0.05 | > 32 | >2 |
| MDAH-2774 | Mutant | 0.67 ± 0.08 | > 32 | >2 |
| SKOV-3 | Mutant | 1.87 ± 0.42 | > 32 | >2 |
Data represent the mean of at least 3 independent experiments ± SEM.