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. 2016 May 23;7(26):40174–40188. doi: 10.18632/oncotarget.9559

Figure 11. Proposed mechanism for the role of BKCa in regulating prostate cancer cell proliferation, migration and invasion.

Figure 11

A. Under normal conditions, BKCa forms complex with integrin αvβ3 and triggers FAK activation/phosphorylation. The activated FAK promotes prostate cancer cell proliferation, migration and invasion. B. Overexpression of BKCa enhance its interaction with integrin αvβ3, recruits more FAK to the integrin αvβ3/BKCa complex and promotes activation/phosphorylation of FAK, resulting in increased cell proliferation, migration and invasion. C. Downregulation of BKCa disrupts the integrin αvβ3/BKCa complex and abolishes BKCa-mediated αvβ3/FAK coupling. Thus, BKCa-induced cancer cell proliferation, migration and invasion are counteracted.