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. 2016 May 23;7(26):40174–40188. doi: 10.18632/oncotarget.9559

Figure 6. Downregulation of BKCa inhibits prostate cancer growth and metastasis in vivo.

Figure 6

A. Growth curves for tumor volume in mouse xenograft models. PC3 cells infected with BK-shRNA lentivirus or Scramble-shRNA were injected subcutaneously into nude mice. The tumor volume was measured every five days for one month. B. BKCa downregulation resulted in a decline of tumor weight. C. Representative images of xenografts (Scale bar 1cm). D-E. Immunohistochemical analysis of BKCa and Ki67 in PC3 xenografts (Scale bar 100 μm). F. Tumor metastasis in mouse xenograft models. PC3 cells stably infected with BK-shRNA or SC-shRNA were injected into the tail vein of nude mice. After 6weeks, the mice were killed. The metastases in the lung were calculated. G-H. Representative images of lungs and hematoxylin-stained sections. All of the data are shown as the means ± se. *P < 0.05.