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. 2016 May 23;7(26):40174–40188. doi: 10.18632/oncotarget.9559

Figure 7. Effects of BKCa channel activator and inhibitor on the proliferation and migration of PC3 cells upon BKCa upregulation or downregulation.

Figure 7

A. Whole-cell K+ currents in PC3 cells in the presence of BKCa channel activator NS1619 (30 μM) and inhibitor IBTX (100 nM). B. Group data of current-voltage relationships in PC3 cells in the presence or absence of 30Mm NS1619 and 100nM IBTX. C. Cell viability was determined by MTT assay in PC3 cells with or without overexpression (or downregulation) of BKCa in the presence of 30μM NS1619 or 100nM IBTX for 48 hr. D. Cell migration was determined by transwell assay in PC3 cells with or without overexpression (or downregulation) of BKCa in the presence of 30μM NS1619 or 100nM IBTX for 24 hr. All the experiments were performed in triplicate. The data are shown as the means ± se. *P < 0.05.