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. 2016 May 26;7(26):40387–40397. doi: 10.18632/oncotarget.9617

Figure 4. β-catenin maintained leukemia cell survival and contributed to sorafenib insensitivity.

Figure 4

A, B. β-catenin protein level and mRNA level were measured by Western blotting and real-time qPCR after Ctnnb1 shRNA vectors infection and puromycin selection for 2 days. *p<0.05. C. Cell viability was measured by CCK-8 assay when cultured for 24, 48, 72 hours, respectively. *p<0.05. D. Cells were treated with different doses of sorafenib for 24 hours. Cell viability was then evaluated by CCK-8 assay. *p<0.05. E. Cells were treated with or without sorafenib (10μM) for 24 hours. F. The percentage of apoptosis in each group. *p<0.05.