Table 1. Relationship between ITGB3 expression and clinicopathological features of AML patients.
| Characteristic | No. | ITGB3 high | ITGB3 low | p value |
|---|---|---|---|---|
| No. of patients | 173 | 87 | 86 | |
| Sex | 0.707 | |||
| Male | 93 | 48 | 45 | |
| Female | 80 | 39 | 41 | |
| Median age, y (range) | 57.8 (21-88) | 52.8 (18-81) | 0.043 | |
| FAB classification, no. | 0.252 | |||
| M0 | 16 | 12 | 4 | |
| M1 | 42 | 19 | 23 | |
| M2 | 39 | 18 | 21 | |
| M3 | 16 | 5 | 11 | |
| M4 | 35 | 18 | 17 | |
| M5 | 18 | 10 | 8 | |
| M6 | 2 | 1 | 1 | |
| M7 | 3 | 3 | 0 | |
| Not Classified | 2 | 1 | 1 | |
| Cytogenetic abnormality, no. | 0.002 | |||
| Favorable | 32 | 7 | 25 | |
| Intermediate | 103 | 56 | 47 | |
| Poor | 36 | 23 | 13 | |
| Unknown | 2 | 1 | 1 | |
| FLT3 mutation rate (%) | 24/85 (27.9) | 26/84 (31.3) | 0.699 | |
| Peripheral blast, % (range) | 61.2 (0-97) | 70.4 (0-100) | 0.006 | |
| Bone marrow blast, % (range) | 74.3 (10-100) | 84.9 (10-100) | 0.010 | |
| Median WBC count, ×109 (range) | 26.3 (1-137) | 49.5 (1-297) | 0.001 | |
| Median Hb concentration, g/dL | 9.8 (6-14) | 9.4 (6-12) | 0.295 | |
| Median platelet count, ×109 (range) | 80.5 (9-351) | 47.5 (8-215) | 0.000 |
Cytogenetic abnormality: according to NCCN guideline.
FAB classification, French-American-British classification; FLT3, Fms-like tyrosine kinase-3; WBC, white blood cell; Hb, hemoglobin.