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. 2016 Mar 31;7(26):40846–40859. doi: 10.18632/oncotarget.8519

Figure 1. Schematic diagram of the full length CDK11 protein kinase.

Figure 1

CDK11 is composed of an N-terminal regulatory region, which has multiple nuclear localization signals (NLS) and a 14-3-3 consensus site, and a carboxy-terminal (C-terminal) catalytic domain that is responsible for its kinase activity. There are two separate domains, an RE domain and a poly-E domain located in the center of the CDK11 protein. The full-length CDK11p110 isoform contains an IRES and a caspase-3 site, which leads to the generation of a larger CDK11p58 and a smaller CDK11p46 isoform, respectively (adapted from Trembley et. al., 2004.). NLS, nuclear localization signal; RE, arginine (R) and glutamic (E) acid residues; IRES, internal ribosomal entry site.