Table 1. Members of CDK family and their functions in cancers.
| CDK Family | Cyclins and Cyclin-like Partners | Gene Locus | Functions in Cancers | Inhibitors |
|---|---|---|---|---|
| CDK1 | A1, A2, B1, B2, (B3), D, E | 10q21.2 | promotes cancer cell cycle G2/M transition and proliferation | Pirarubicin, Flavopiridol, Dinaciclib, Seliciclib, Roscovitine, Milciclib, Roniciclib, AZ703, UCN-01, P276-00, AT7519, AZD5438, SCH727965, RGB-286638 |
| CDK2 | A1, A2, B1, B3, D, E1, E2, Cables1, SpdYA, SpdYC |
12q13.2 | promotes cancer cell cycle G1/S transition and proliferation | Seliciclib, Flavopiridol, Roscovitine, MLN4924, Dinaciclib, Roniciclib, AZ703, UCN-01, SNS-032, AT7519, SCH727965, RGB-286638, AZD5438 |
| CDK3 | A1, A2, E1, E2, C, Cables1 | 17q25.1 | helps cancer cells to efficiently exit the G0 state and enter the G1 phase, facilitates cell proliferation | TG-02, AT-7519, RGB-286638 |
| CDK4 | D1, D2, D3 | 12q14.1 | promotes cancer cell G1 phase progression and proliferation | Palbociclib, Flavopiridol, Abemaciclib, Dinaciclib, Ribociclib, Milciclib, Roniciclib, P276-00, LY2835219, AT7519, MM-D37K, RGB-286638, AZD5438 |
| CDK5 | p35, p39 (D-, E and G-type cyclins), Cables1 |
7q36.1 | unknown | Roscovitine, Flavopiridol, Milciclib, SCH727965, AZD5438, RGB-286638 |
| CDK6 | D1, D2, D3 | 7q21.2 | promotes cancer cell G1 phase progression and proliferation | Palbociclib, Flavopiridol, Abemaciclib, Ribociclib, LY2835219, AT7519, RGB-286638 |
| CDK7 | H | 5q13.2 | promotes cell cycle progress, RNA transcription, and cancer cell proliferation | Roscovitine, Flavopiridol, Roscovitine, Milciclib, Roniciclib, SNS-032, AT7519, RGB-286638, AZD5438 |
| CDK8 | C, (K) | 13q12.13 | activates RNA transcription and promotes cancer cell proliferation | unknown |
| CDK9 | K, T1, T2 | 9q34.11 | promotes RNA transcription elongation and cancer cell proliferation | Flavopiridol, Roscovitine, Roniciclib, SNS-032, AZD5438, P276-00, AT7519, SCH727965, RGB-286638 |
| CDK10 | M | 16q24.3 | promotes RNA transcription and cancer cell proliferation | unknown |
| CDK11 | D3, L1, L2 | 1p36.33 | transcription, RNAsplicing; cell cycle: G2/M | unknown |
| CDK12 | L1, L2, K | 17q12 | promotes RNA transcription elongation, splicing, and cancer cell proliferation | unknown |
| CDK13 | L1, L2, K | 7p14.1 | promotes RNA transcription elongation, splicing, and cancer cell proliferation | unknown |
| CDK14 | D3, Y | 7q21.13 | links cell cycle regulators and Wnt signaling, promotes cancer cell proliferation, migration, and invasion | unknown |
| CDK15 | unknown | 2q33.1 | promotes cancer cell cycle progression and proliferation | unknown |
| CDK16 | Y, p35, Cables1 | Xp11.3 | promotes cancer cell cycle progression and proliferation | unknown |
| CDK17 | Cables1 | 12q23.1 | unknown | unknown |
| CDK18 | K, A | 1q32.1 | unknown | unknown |
| CDK19 | C | 6q21 | activates RNA transcription and promotes cancer cell proliferation | unknown |
| CDK20 | H | 9q22.1 | unknown | Unknown |