| Breast Cancer |
immunohistochemistry; RNAi; immunofluorescence assay; cell viability assay; cell colony formation assay; cell migration assay; western blot; flow cytometry analysis; xenograft RNAi studies |
promotes breast cancer cell proliferation, growth, migration and cell cycle progression; inhibits breast cancer cell apoptosis, negatively correlated with breast cancer patient clinical prognosis |
| Osteosarcoma |
systematic Kinome shRNA screening; CRISPR, RNAi; cell proliferation assay; apoptosis assay; western blot; immunofluorescence assay; immunohistochemistry; xenograft RNAi studies |
promotes osteosarcoma cell proliferation, growth; inhibits osteosarcoma cell apoptosis; negatively correlated with osteosarcoma patient clinical prognosis |
| Liposarcoma |
immunohistochemistry; RNAi; cell proliferation assay; western blot; immunofluorescence assay; chemotherapeutic response assay |
promotes liposarcoma cell growth, survival; inhibits liposarcoma cell apoptosis; desensitizes liposarcoma cell to chemotherapy |
| Multiple Myeloma |
high-throughput siRNA screening;RNA microarray hybridization |
promotes myeloma cell proliferation and survival |
| Colon Cancer |
high-throughput RNAi screening |
acts as a positive modulator of the Wnt/β-catenin pathway in colon cancer |
| Cervical Cancer |
RNAi; microtubule regrowth assays |
promotes centrosome maturation and bipolar spindle morphogenesis in cervical cancer cells |
| Acute Myeloid Leukemia (AML) |
CRISPR-based knockout with RNAi |
crucial for TSC2-deficient AML cell growth |
