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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Curr Opin HIV AIDS. 2016 Nov;11(6):569–575. doi: 10.1097/COH.0000000000000317

Figure 1. Maturation of breadth requires selection of rare B cell precursors, and their retention and maturation towards breadth.

Figure 1

Germline-targeting approaches enable selection and activation of rare B cells, but if these do not acquire mutations that enable them to bind to more native-like boosting immunogens, they will not be boosted. Acquisition of sufficient productive mutations to enable binding to boosting antigens will be required for maturation of Tier-2 strain-specific neutralizing antibodies.